This note provides a comprehensive overview of the Human Structure & Function course (HBS109) at Deakin University. It covers a wide range of topics related to the organization and functioning of the human body. The note begins by discussing the different organ systems, delving into their structures and functions. It then moves on to explore the fundamental aspects of cell structure and function, highlighting their significance as the building blocks of life. The note also delves into the various types of tissues and their roles within the body. The skeletal system is examined, shedding light on the intricate framework of bones and their vital functions. Moving on, muscular tissue is explored, elucidating the different types of muscles and their functions. The note continues with an exploration of the nervous system, encompassing the brain, spinal cord, and nerves. The endocrine system, responsible for hormone production, is also discussed. The note then shifts to the topics of blood composition, immunity, and the cardiovascular system, covering the heart, blood vessels, and circulation. The respiratory system, including the lungs and gas exchange, is also examined. The urinary system, which includes the kidneys and bladder, is discussed in relation to urine production. Finally, the note concludes by delving into the digestive system and its various components responsible for digestion and nutrient absorption. Overall, this comprehensive note provides an extensive understanding of the human body’s structure and function, offering valuable insights into the complex systems that enable our daily functioning.